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and melatonin preconditioning enhances ERC efficacy via antioxidant protection, significantly lowering both the disease activity index and tissue damage scores ( In the treatment of type 1 diabetes mellitus (T1DM), ( In sepsis treatment research, ( 3.2.7 Molecular mediators and signal transduction cascades MenSCs exert reparative effects via the paracrine release of small extracellular vesicles (sEVs), which mediate multiple signaling pathways