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Pyruvate (10 mM), glutamate (20 mM) and succinate (10 mM) and glycerol-phosphate were added to evaluate ADP-stimulated respiration when NADH and succinate-linked pathways are simultaneously transferring electrons to the Q junction (Oxphos complexes I + II)

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To support this finding, few in vitro studies claimed that collagen peptides can accrue in cartilage with high doses, upregulate chondrocytes to produce macromolecules of the extracellular matrix (ECM), and upregulate and downregulate the osteoblast and osteoclast activity, respectively [125,133,134,135,136]

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