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Future development should prioritize the design of smart hydrogels with responsive degradation kinetics, patient-specific mechanical tailoring, and integrated multi-modal regulation (e.g., combined growth factor delivery, antioxidant activity, and mechanical sensing) to address the complexity of the degenerative disc niche and accelerate the clinical translation of MSC-based hydrogel therapies for DDD
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A novel distal upstream hypoxia response element regulating oxygen-dependent erythropoietin gene expression
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