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Clin Exp Immunol 138(1):83–93 [DOI] [PMC free article] [PubMed] [Google Scholar] Jonca N, Leclerc EA, Caubet C, Simon M, Guerrin M, Serre G (2011) Corneodesmosomes and corneodesmosin: from the s tratum corneum cohesion to the pathophysiology of genodermatoses

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The discovery paper in Cell Metabolism reports exactly that trade-off: in vitro, retatrutide shows balanced glucagon-receptor and GLP-1-receptor activity but more GIP-receptor activity — the incretin arms are weighted to offset the glycaemic cost of the glucagon arm (DOI)