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Research has confirmed AOD9604’s selective lipolytic activity in adipocyte models and rodent pre-clinical studies characterising triglyceride hydrolysis stimulation, free fatty acid mobilisation, and fat mass reduction without detectable GH receptor activation, IGF-1 elevation, insulin resistance induction, or mitogenic signalling

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Blocking NNMT keeps nicotinamide in the NAD+ salvage pathway and S-adenosylmethionine available for polyamine synthesis, and in mouse models of diet-induced obesity that translates into smaller adipocytes, lower adipose mass, better oral glucose tolerance and less hepatic steatosis, with no measurable change in food intake